SCREENING OF A FOCUSED UBIQUITIN-PROTEASOME PATHWAY INHIBITOR LIBRARY IDENTIFIES SMALL MOLECULES AS NOVEL MODULATORS OF BOTULINUM NEUROTOXIN TYPE A TOXICITY

Botulinum neurotoxins (BoNTs) are known as the most potent bacterial toxins, which can cause potentially deadly disease botulism.BoNT Serotype A (BoNT/A) is the most studied serotype as it is responsible for most human botulism cases, and its formulations are extensively utilized in clinics for therapeutic and cosmetic applications.BoNT/A Carbs and

Manoj Sharma1, Deepika R Sharma1, Vikram Singh1, RB Panwar2, HS Hira3, Bishav Mohan4, Naveen Kumar4, SK Sharma5, Rajeev Gupta61Clinical Research Division, Panacea-Biotec Ltd, New Delhi; 2SP Medical College, Bikaner; 3Maulana Azad Medical College, New Delhi; 4Dayanand Medical College, Ludhiana; 5SMS Medical College, Jaipur; 6Monilek Hospital and Res

Industrial machines regularly work at their limits causing excessive long-term vibrations that deteriorate their movement, stability, and precision.In this sense, reference profiles are able to reduce the detrimental vibration effects by manipulating the machine motion dynamics using predefined movement trajectories.Most of the approaches for lesse

On the edge of a freeway already stepped by Bradbury, it is sustained that writing happens and that —from the corner of a school in the Department of Oruro, Bolivia, up to the niche of Walter Benjamin’s childhood in Berlin— the inscription’s material and timely environment corresponds to the theater of TopMale a ferocious li

Zhang H, Zhao H, He X, Xi F, Liu J.Cancer Manag Res.2020;12:9813–9824.We, the Editor and Publisher of the journal Cancer Management and Research are retracting the published article.Following publication of the article, concerns were raised regarding the duplication of images from Figures 2, 4 and 5 with images from unrelated articles.Specif